For Research Use Only. Not for human or veterinary use.
KPV is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 1 listed specification. Review product codes, storage guidance and COA status, then request a wholesale quotation. Published COA documentation is available for selected specifications.
Volume discounts are available for larger purchasing plans. Please contact us for a quotation.
Delivery includedUsually within 7 days after dispatch
Quality resolutionRefund or replacement when approved
24/7 contactWholesale assistance on WhatsApp
Product profile
About KPV
KPV is a synthetic tripeptide composed of lysine (K), proline (P), and valine (V), corresponding to the C-terminal sequence (amino acids 11–13) of α-melanocyte-stimulating hormone (α-MSH). As an endogenous peptide, KPV retains the core anti-inflammatory activity of α-MSH while completely eliminating its pigmentary (melanogenic) effects, making it a potentially safer anti-inflammatory candidate.
Its mechanism of action is distinct. Research confirms that KPV does not exert its effects primarily through classical melanocortin receptors but rather through the inhibition of the NF-κB signaling pathway. Specifically, KPV suppresses nuclear translocation of p65RelA and stabilizes IκBα to block the inflammatory cascade. Furthermore, KPV can be actively transported into cells via the PepT1 transporter expressed on intestinal epithelial and immune cells, enabling it to exert anti-inflammatory effects in tissues such as the gut. Recent studies have also highlighted KPV's potent antioxidant activity, as it scavenges reactive oxygen species (ROS) and inhibits MAPK/NF-κB pathways and pyroptosis, protecting cells from damage induced by environmental pollutants such as fine particulate matter (PM10).
Main functions
1.Potent Anti-Inflammatory and Immunomodulatory Effects: Inhibits NF-κB activation and reduces pro-inflammatory cytokines (e.g., IL-1β, IL-8), demonstrating efficacy across multiple inflammatory models.
2.Skin Protection and Anti-Aging: Protects keratinocytes from oxidative damage and inflammation induced by environmental pollutants (PM10) by scavenging ROS and inhibiting pyroptotic signaling pathways, showing potential for functional cosmetics and dermatological treatments.
3.Supports Gut Health: In animal models, oral KPV alleviates symptoms of DSS- and TNBS-induced colitis, including weight recovery and reduced histological inflammation, suggesting it could be a novel therapeutic option for inflammatory bowel disease (IBD).
4.Potential Cardiovascular Protection: A recent study demonstrated that carrier-free nanoparticles self-assembled from KPV and rapamycin effectively inhibit vascular calcification in mice via anti-inflammatory and autophagy-activating mechanisms.
5.Unique Mechanism of Action: Unlike many peptides that act via GPCRs, KPV primarily functions through direct modulation of intracellular transcription factors (NF-κB) and transport proteins (PepT1), offering a distinct mode of action and potential for synergistic applications.
Health-conscious individuals seeking to improve skin health and combat environmental damage and photoaging.
Individuals seeking gut health support and adjunctive management for inflammatory bowel conditions.
Order formatOne box accepted
QuotationConfirmed on WhatsApp
DeliveryShipping and duties included
DocumentationPublished COA or available on request
Research product specification
Product information
KPV is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 1 listed specification. Review product codes, storage guidance and COA status, then request a wholesale quotation. Published COA documentation is available for selected specifications.
Handling information
Storage guidance
Keep unopened lyophilized products protected from light and moisture; store at 2-8°C short term or -20°C long term. After reconstitution, refrigerate according to product documentation and minimize freeze-thaw cycles.
Customer-first resolution
Report quality concerns within 14 days of delivery
Contact us with the order number, batch details and available photos. Opened products are accepted for review. When a quality claim is approved, you may choose a full refund or replacement shipment.
