YZFyzfpeptide.comMazdutide5mgFor Research Use Only
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Research product specification
MAZ5
Mazdutide
For Research Use Only. Not for human or veterinary use.
Mazdutide is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 3 listed specifications. Review product codes, storage guidance and COA status, then request a wholesale quotation. Batch documentation is available on request.
Volume discounts are available for larger purchasing plans. Please contact us for a quotation.
Delivery includedUsually within 7 days after dispatch
Quality resolutionRefund or replacement when approved
24/7 contactWholesale assistance on WhatsApp
Product profile
About Mazdutide
Mazdutide (IBI362) is a synthetic, innovative peptide molecule and a first‑in‑class dual agonist of the glucagon‑like peptide‑1 receptor (GLP‑1R) and the glucagon receptor (GCGR). Its unique mechanism of action involves simultaneous activation of both receptors: GLP‑1R activation delivers classical incretin effects including appetite suppression, delayed gastric emptying, and enhanced insulin secretion, while GCGR activation directly targets the liver and adipose tissue to promote hepatic fat breakdown, fatty acid oxidation, and energy expenditure. This dual‑pathway synergy endows mazdutide with superior efficacy in weight reduction, glycemic control, and metabolic improvement compared to selective GLP‑1 receptor agonists. As a domestically developed innovative drug in China, mazdutide has demonstrated positive outcomes in multiple Phase III clinical trials and has been approved in China for body weight management and glycemic control in adults with type 2 diabetes.
Main functions
1.Significant Weight Reduction: In the GLORY‑1 Phase III trial involving 610 Chinese adults with overweight or obesity, 48‑week treatment resulted in mean weight loss of 11.0% (4 mg) and 14.0% (6 mg), versus 0.3% with placebo. A higher 9‑mg dose achieved a mean weight reduction of 16.65% over 60 weeks. Meta‑analysis confirms an overall weight loss magnitude of 12.42%.
2.Superior Glycemic Control: In patients with type 2 diabetes, 24‑week treatment reduced HbA1c by 1.57% (4 mg) to 2.15% (6 mg), compared to a 0.14% reduction with placebo, demonstrating potent glucose‑lowering efficacy.
3.Multiple Cardiometabolic Benefits: Significantly reduces blood pressure, total cholesterol, and LDL‑C levels, and effectively lowers serum uric acid.
4.Marked Improvement in Liver Health: The 6‑mg dose achieves up to 80.2% reduction in liver fat content and shows beneficial effects on MASH‑related fibrosis. For T2DM patients with residual moderate‑to‑severe fatty liver after semaglutide treatment, mazdutide offers distinct advantages in hepatic lipid metabolism regulation via direct GCGR activation.
5.Cardiovascular Safety Profile: Preclinical studies indicate mazdutide can increase human atrial contractile force, potentially explaining some cardiac effects observed clinically, though no clear cardiovascular risk signals were identified during the study period. The 48‑week study showed minimal heart rate changes with no indication of increased cardiovascular risk.
Overweight or obese individuals requiring substantial weight loss, particularly those with suboptimal response to existing GLP‑1‑based therapies.
Patients with type 2 diabetes complicated by obesity, needing both potent glycemic control and significant weight reduction.
Individuals with metabolic syndrome complicated by metabolic dysfunction‑associated steatotic liver disease (MASLD/MASH) or hyperuricemia.
Order formatOne box accepted
QuotationConfirmed on WhatsApp
DeliveryShipping and duties included
DocumentationPublished COA or available on request
Research product specification
Product information
Mazdutide is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 3 listed specifications. Review product codes, storage guidance and COA status, then request a wholesale quotation. Batch documentation is available on request.
Handling information
Storage guidance
Keep unopened lyophilized products protected from light and moisture; store at 2-8°C short term or -20°C long term. After reconstitution, refrigerate according to product documentation and minimize freeze-thaw cycles.
Customer-first resolution
Report quality concerns within 14 days of delivery
Contact us with the order number, batch details and available photos. Opened products are accepted for review. When a quality claim is approved, you may choose a full refund or replacement shipment.
