YZFyzfpeptide.comPinealon10mlFor Research Use Only
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Research product specification
PI10
Pinealon
For Research Use Only. Not for human or veterinary use.
Pinealon is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 1 listed specification. Review product codes, storage guidance and COA status, then request a wholesale quotation. Batch documentation is available on request.
Volume discounts are available for larger purchasing plans. Please contact us for a quotation.
Delivery includedUsually within 7 days after dispatch
Quality resolutionRefund or replacement when approved
24/7 contactWholesale assistance on WhatsApp
Product profile
About Pinealon
Pinealon is a synthetic tripeptide composed of three amino acids—glutamic acid (Glu), aspartic acid (Asp), and arginine (Arg)—with the sequence Glu-Asp-Arg (EDR). This short peptide belongs to a class of neuroactive peptides with potential bioregulatory functions and is part of a peptide family studied by the St. Petersburg Institute of Bioregulation and Gerontology. Its core mechanism of action operates at the cellular level: Pinealon inhibits the accumulation of reactive oxygen species (ROS), modulates ERK1/2 signaling pathway activation, reduces necrosis and spontaneous apoptosis, and stimulates the functional activity of the main cellular elements of brain tissue.
Main functions
"1.Neuroprotection and Antioxidant Effects: In vitro, Pinealon dose-dependently restricts ROS accumulation induced by oxidative stress and reduces necrosis in cerebellar granule cells, neutrophils, and PC12 cells. In a rat model of prenatal hyperhomocysteinemia, Pinealon significantly improved offspring spatial orientation and learning ability while making their cerebellar neurons more resistant to oxidative stress.
2.Cognitive Function Support: In aged rhesus macaques, a 10-day oral Pinealon course significantly reduced training duration (p0.01) and motor response time (p0.001), while improving selective attention and spatial orientation. Researchers attributed these effects to enhanced energy supply to muscle tissue and strengthened fronto-temporo-parietal brain connections. A recent mouse study also observed a trend toward improved working memory with Pinealon, without detectable adverse effects.
3.Nuclear Targeting and Epigenetic Regulation: Fluorescently labeled Pinealon has been shown to penetrate HeLa cell membranes and enter the nucleus and nucleolus. In vitro experiments demonstrated that Pinealon can specifically bind to certain DNA sequences (e.g., CAG-containing oligonucleotides), suggesting potential epigenetic regulatory mechanisms for gene expression.
4.Sleep-Wake Modulation Potential: A 2026 review categorizes Pinealon as a ""sleep and recovery optimization therapeutic peptide,"" with mechanisms involving mitochondrial antioxidants and neuronal support, potentially influencing circadian regulators to promote recovery."
Recommended audience
"Health-conscious individuals focused on neuroprotection, anti-aging, and cognitive function support (research applications).
Basic and preclinical research areas involving age-related cognitive decline and oxidative stress-related neurological conditions.
Researchers investigating neuronal metabolism, mitochondrial function, and recovery optimization."
Order formatOne box accepted
QuotationConfirmed on WhatsApp
DeliveryShipping and duties included
DocumentationPublished COA or available on request
Research product specification
Product information
Pinealon is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 1 listed specification. Review product codes, storage guidance and COA status, then request a wholesale quotation. Batch documentation is available on request.
Handling information
Storage guidance
Keep unopened lyophilized products protected from light and moisture; store at 2-8°C short term or -20°C long term. After reconstitution, refrigerate according to product documentation and minimize freeze-thaw cycles.
Customer-first resolution
Report quality concerns within 14 days of delivery
Contact us with the order number, batch details and available photos. Opened products are accepted for review. When a quality claim is approved, you may choose a full refund or replacement shipment.
