For Research Use Only. Not for human or veterinary use.
Selank is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 2 listed specifications. Review product codes, storage guidance and COA status, then request a wholesale quotation. Published COA documentation is available for selected specifications.
Volume discounts are available for larger purchasing plans. Please contact us for a quotation.
Delivery includedUsually within 7 days after dispatch
Quality resolutionRefund or replacement when approved
24/7 contactWholesale assistance on WhatsApp
Product profile
About Selank
Selank is a synthetic heptapeptide (sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro) and a synthetic analogue of the endogenous immunomodulatory peptide tuftsin, stabilized by the addition of a Pro-Gly-Pro (PGP) sequence at the C-terminus. The drug is registered for medical use in the Russian Federation, primarily for the treatment of generalized anxiety disorder and neurasthenia. Selank's mechanism of action is multi-targeted: it acts as a positive allosteric modulator of GABA-A receptors, enhancing GABAergic inhibitory neurotransmission, while also dose‑dependently inhibiting enkephalin-degrading enzymes in plasma (IC50 = 15 μM), thereby prolonging the half‑life of endogenous enkephalins. Selank is distinguished by its lack of sedative, muscle-relaxant, and addictive effects—side effects typical of classical benzodiazepines.
Main functions
"1.Significant Anxiolytic Effect: In animal models, Selank enhances the anxiolytic effect of benzodiazepines while attenuating their sedative and muscle-relaxant side effects. Clinical studies show its anxiolytic efficacy comparable to classical benzodiazepines, without inducing dependence or memory impairment.
2.Neuroprotection and Cerebral Ischemia Protection: In a rat model of focal cerebral ischemia, Selank modulated 118 differentially expressed genes (DEGs) as early as 4.5 hours post‑administration, significantly reversing ischemia‑induced gene expression disturbances across pathways including immunity, antigen processing, and the complement system.
3.Anti‑Inflammatory and Immunomodulatory Effects: In a ""social"" stress model, Selank restored serum levels of caspase‑3, caspase‑8, and TNF‑α while upregulating neurotrophic factors BDNF and NGF, demonstrating anti‑apoptotic and stress‑protective effects. In vitro, Selank downregulated inflammation‑related genes such as Il2rg and Xcr1 in mouse spleen.
4.Cognitive Enhancement and Nootropic Effects: Selank exhibits clear neurotrophic and cognitive‑enhancing properties. In an acute restraint stress model, it significantly altered the expression of 549 genes in the rat hippocampus (2 hours post‑administration), involving pathways related to neural impulse transmission and antigen processing.
5.Precision Regulation at the Molecular Level: Transcriptomic studies reveal that Selank's effects are ""stress‑dependent""—it exerts no significant impact on gene expression under non‑stress conditions but actively regulates molecular pathways under pathological states (stress, ischemia), suggesting favorable targeting and safety profiles."
Recommended audience
"Individuals with anxiety spectrum disorders, including generalized anxiety disorder, panic disorder, and neurasthenia.
Patients seeking anxiolytic effects without the sedative, muscle‑relaxant, or addictive side effects associated with traditional benzodiazepines.
Individuals requiring neuroprotection and functional recovery following ischemic brain injury (e.g., stroke).
Health‑conscious individuals focused on chronic stress management, cognitive function improvement, and neurological health."
Order formatOne box accepted
QuotationConfirmed on WhatsApp
DeliveryShipping and duties included
DocumentationPublished COA or available on request
Research product specification
Product information
Selank is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 2 listed specifications. Review product codes, storage guidance and COA status, then request a wholesale quotation. Published COA documentation is available for selected specifications.
Handling information
Storage guidance
Keep unopened lyophilized products protected from light and moisture; store at 2-8°C short term or -20°C long term. After reconstitution, refrigerate according to product documentation and minimize freeze-thaw cycles.
Customer-first resolution
Report quality concerns within 14 days of delivery
Contact us with the order number, batch details and available photos. Opened products are accepted for review. When a quality claim is approved, you may choose a full refund or replacement shipment.
