YZFyzfpeptide.comLipo-BSpecification on requestFor Research Use Only
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Research product specification
LC120
Lipo-B
For Research Use Only. Not for human or veterinary use.
Lipo-B is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 1 listed specification. Review product codes, storage guidance and COA status, then request a wholesale quotation. Batch documentation is available on request.
Volume discounts are available for larger purchasing plans. Please contact us for a quotation.
Delivery includedUsually within 7 days after dispatch
Quality resolutionRefund or replacement when approved
24/7 contactWholesale assistance on WhatsApp
Product profile
About Lipo-B
Lipo-B (LC120) is a lipopeptide compound formed by covalently linking a lipophilic moiety (Lipo) to a specific peptide sequence, belonging to the category of investigational immunomodulatory molecules. Its core design originates from pioneering research aimed at inducing antigen-specific immune tolerance through efficient antigen presentation. By attaching a lipophilic palmitic acid chain to the N-terminus of the peptide, the molecule effectively binds to serum albumin, prolonging its half-life and enabling targeted enrichment at antigen-presenting cells (APCs) in lymph nodes.
Main functions
"1.Efficient Targeted Antigen Presentation: In vitro and in vivo studies demonstrate that its amphiphilic structure allows for more effective uptake and presentation by APCs, significantly enhancing the potency and duration of antigen-specific immunomodulatory effects, far surpassing unmodified soluble peptides.
2.Induces Antigen-Specific Immune Tolerance: In the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), treatment with Lipo-B carrying key CD4+ T-cell epitopes effectively suppresses pathogenic T-cell activity and induces regulatory T-cell (Treg) generation, thereby significantly delaying diabetes onset and reducing incidence.
3.Delays Disease Progression in Established Models: In NOD mice that had already developed acute hyperglycemia, short-term treatment with a mixture of Lipo-B(9-23) and other β-cell antigen lipopeptides successfully delayed progression to end-stage diabetes, whereas equivalent doses of unmodified soluble peptides were entirely ineffective."
Recommended audience
"Autoimmune Disease Researchers: Scientists focused on developing antigen-specific immunotherapies (rather than broad immunosuppression) for treating or preventing autoimmune diseases such as type 1 diabetes and multiple sclerosis.
Peptide Vaccine and Immunotherapy Developers: Pharmaceutical researchers interested in chemical modification strategies, such as lipidation, to enhance peptide vaccine immunogenicity or induce immune tolerance.
DocumentationPublished COA or available on request
Research product specification
Product information
Lipo-B is listed for legitimate laboratory and research procurement. This 99%+ research-use product is available in 1 listed specification. Review product codes, storage guidance and COA status, then request a wholesale quotation. Batch documentation is available on request.
Handling information
Storage guidance
Keep unopened lyophilized products protected from light and moisture; store at 2-8°C short term or -20°C long term. After reconstitution, refrigerate according to product documentation and minimize freeze-thaw cycles.
Customer-first resolution
Report quality concerns within 14 days of delivery
Contact us with the order number, batch details and available photos. Opened products are accepted for review. When a quality claim is approved, you may choose a full refund or replacement shipment.
